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首页> 外文OA文献 >Intrauterine growth restriction and the sex specific programming of leptin and peroxisome proliferator-activated receptor [gamma (PPAR gamma]) mRNA expression in visceral fat in the lamb
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Intrauterine growth restriction and the sex specific programming of leptin and peroxisome proliferator-activated receptor [gamma (PPAR gamma]) mRNA expression in visceral fat in the lamb

机译：胎儿生长受限和瘦素和过氧化物酶体增殖物激活受体[γ（ppaRγ））mRNa在羊内脏脂肪中的性别特异性编程

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Being born small is associated with an increased risk of visceral obesity and insulin resistance in adult life. We have investigated the effect of IUGR on adipogenic and lipogenic gene expression in visceral fat in the lamb at 3 wk of age. Perirenal fat mass, but not adipocyte size was greater in females than males, independent of birth weight. Plasma insulin concentrations during the first 24 h after birth predicted the size of the adipocytes and expression of adiponectin in visceral adipose tissue in both males and females. In females, plasma nonesterified fatty acids (NEFA) concentrations during the first 24 h after birth were directly related to peroxisome proliferator-activated receptor (PPAR) mRNA expression in the perirenal fat depot at 3 wk of age. In the males, in contrast to the females, PPAR and leptin expression in perirenal visceral fat were significantly lower in IUGR compared with control lambs. Thus, the early nutritional environment programs adipocyte growth and gene expression in visceral adipose tissue. The differential effect of sex and IUGR on PPAR and leptin expression in visceral fat may be important in the subsequent development of visceral obesity and the insulin resistant phenotype in later life. (Pediatr Res 66: 59–65, 2009)
机译：小出生与成年后内脏肥胖和胰岛素抵抗的风险增加有关。我们研究了IUGR对3周龄羔羊内脏脂肪中成脂和生脂基因表达的影响。与出生体重无关，女性的肾上腺脂肪量，而非脂肪细胞大小大于男性。出生后头24小时内的血浆胰岛素浓度可预测男性和女性内脏脂肪组织中脂肪细胞的大小和脂联素的表达。在女性中，出生后最初24小时内血浆非酯化脂肪酸（NEFA）的浓度与3周龄肾周脂肪储库中的过氧化物酶体增殖物激活受体（PPAR）mRNA表达直接相关。在雄性中，与雌性相比，与对照羔羊相比，IUGR中肾周内脏脂肪中的PPAR和瘦素表达显着降低。因此，早期的营养环境可以控制内脏脂肪组织中脂肪细胞的生长和基因表达。性别和IUGR对内脏脂肪中PPAR和瘦素表达的差异作用可能在随后的内脏肥胖和胰岛素抵抗表型的发展中起重要作用。 （Pediatr Res 66：59–65，2009）

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